Physiological Stimuli of Solution to Gel Depot Systems Containing Clotrimazole for Oral Thrush
نویسندگان
چکیده
The scope of the present study is to develop a prolonged the delivery of the active drug in the oral cavity using a suitable carrier such as in situ gels which can effectively deliver the drug for an extended duration of time hence not only reduce the systemic side effects but also improve the therapeutic efficacy, patient compliance. Local drug delivery systems are better suitable for antifungal drugs particularly for oral thrush. The viscosity of in situ system was found to be in the range (42.8 to 49.55 cps) for the sol, whereas for the gels it was up to (47820 cps). The maximum gel strength and mucoadhesion was found to be up to (120 seconds) and (4211 dynes/cm
منابع مشابه
Epidemiology of oral candidiasis in HIV-infected patients: colonization, infection, treatment, and emergence of fluconazole resistance.
PURPOSE To study the epidemiology of oral candidiasis and the effect of treatment of thrush in human immunodeficiency virus (HIV)-infected patients. PATIENTS AND METHODS We conducted a prospective observational study of 92 patients over 1 year, including a nonblinded, randomized treatment trial of thrush with clotrimazole troches or oral fluconazole. Oral sites were cultured monthly and when ...
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